Based at UCL Great Ormond Street Institute of Child Health we are able to undertake contract research, driven by our passion for advancing translational antimicrobial research and making a positive impact in the field.
We have access to cutting-edge knowledge, resources, and a network of experts. Our roots in the university environment ensure that we stay at the forefront of scientific advancements and are continuously engaged in collaborative research.
We are proud of our track record in antimicrobial studies. Our dedicated efforts have resulted in several notable publications, demonstrating our commitment to advancing the understanding and treatment of infectious diseases. These publications reflect our expertise and serve as a testament to the quality of our work.
Our antimicrobial laboratory facilities are state-of-the-art, providing a robust infrastructure for conducting sophisticated experiments and analyses. Equipped with the latest technologies and operated by skilled professionals, our labs enable us to deliver accurate and reliable results.
At our core, we value innovation, integrity, and a relentless pursuit of scientific excellence. We strive to make a difference by developing novel approaches, improving existing methodologies, and contributing to the global fight against antimicrobial resistance.
We are committed to using, researching and developing alternatives to animal experiments and none of our research has involved animals. read more...
We embrace the entrepreneurial spirit, combining academic rigor with practical applications. We are driven by a vision to translate scientific discoveries into tangible solutions that benefit patients, healthcare providers, and society as a whole.
Replacing animal experiments: we are committed to using, researching and developing alternatives to animal experiments.
Readman, J. B., Acman, M., Hamawandi, A., Chiu, C. -. H., Sharland, M., Lindsay, J. A., & Standing, J. F. (2023). Cefotaxime/sulbactam plus gentamicin as a potential carbapenem- and amikacin-sparing first-line combination for neonatal sepsis in high ESBL prevalence settings. Journal of Antimicrobial Chemotherapy. doi:10.1093/jac/dkad177
Kembou-Ringert, J. E., Readman, J., Smith, C. M., Breuer, J., & Standing, J. F. (2022). Applications of the hollow-fibre infection model (HFIM) in viral infection studies. Journal of Antimicrobial Chemotherapy. doi:10.1093/jac/dkac394
Gastine, S., Obiero, C., Kane, Z., Williams, P., Readman, J., Murunga, S., . . . Standing, J. F. (2022). Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis. Journal of Antimicrobial Chemotherapy, 77 (2), 448-456. doi:10.1093/jac/dkab413
Sadouki, Z., McHugh, T. D., Aarnoutse, R., Ortiz Canseco, J., Darlow, C., Hope, W., . . . Kloprogge, F. (2021). Application of the hollow fibre infection model (HFIM) in antimicrobial development: a systematic review and recommendations of reporting. Journal of Antimicrobial Chemotherapy. doi:10.1093/jac/dkab160
Standing JF. Understanding and applying pharmacometric modelling and simulation in clinical practice and research. Br J Clin Pharmacol. 2017 Feb;83(2):247-254. doi: 10.1111/bcp.13119
Readman JB, Dickson G, Coldham NG. Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime. Front Microbiol. 2016 Mar 24;7:373 doi: 10.3389/fmicb.2016.00373
Germovsek E, Barker CIS, Sharland M, Standing JF. Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance. Clin Pharmacokinet. 2019 Jan;58(1):39-52. doi: 10.1007/s40262-018-0659-0.
Barker CI, Germovsek E, Hoare RL, Lestner JM, Lewis J, Standing JF. Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology. Adv Drug Deliv Rev. 2014 Jun;73(100):127-39. doi: 10.1016/j.addr.2014.01.002.
Antimicrobial Pharmacokinetic Pharmacodynamic Laboratory
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
London WC1N 1EH
Email: mail@antimicrobialpkpdlab.co.uk hfim@ucl.ac.uk
